TARGETING TREATMENT RESISTANCE: UNVEILING THE POTENTIAL OF RNA METHYLATION REGULATORS AND TG-101,209 IN PAN-CANCER NEOADJUVANT THERAPY

Targeting treatment resistance: unveiling the potential of RNA methylation regulators and TG-101,209 in pan-cancer neoadjuvant therapy

Abstract Background Tumor recurrence and mortality rates remain challenging in cancer patients despite comprehensive treatment.Neoadjuvant chemotherapy and immunotherapy aim to eliminate residual tumor cells, reducing the risk of recurrence.However, drug resistance during neoadjuvant therapy is a significant hurdle.Recent studies suggest a correlat

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Gene expression regulation by retinoic acid

Over the last quarter century, more than 532 genes have been put forward as regulatory targets of retinoic acid.In some cases this control is direct, driven by a liganded heterodimer of retinoid receptors bound to a DNA response element; in others, it is indirect, reflecting the actions of intermediate transcription factors, non-classical associati

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